clindamycin and lupus

The https:// ensures that you are connecting to the On the other hand, there are few reports related to blood concentrations of TMP/SMZ in the Chinese population, so the drug's metabolism may be racially differentiated. Baykal C, Kobaner GB, Copur S, Buyukbabani N. Acta Dermatovenerol Croat. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents. Before If any of these effects last or get worse, tell your doctor or pharmacist promptly. MeSH What is clindamycin used for? Types, dosage, and side effects Clipboard, Search History, and several other advanced features are temporarily unavailable. Pneumocystis jirovecii pneumonia (PCP) is a serious opportunistic infection disease. Consult your doctor for more details. The oral capsule should not be given to children who are unable to swallow capsules; use the oral solution instead. 2006;145:758-64. It works to treat bacterial infections when penicillin is not an option. 1) on day 10. . It is recommended that Caspofungin combined with clindamycin as an alternative in patients with treatment failure or intolerance to TMP/SMZ may achieve satisfactory therapeutic effects [11]. Chronic pressure on the skin is probably involved in the onset of skin lesions in hand-foot eruptions induced by tyrosine kinase inhibitors (sorafenib and sutinib). Infektionskr. Drug-induced lupus (DIL) is one of the most widely described drug-induced rheumatologic syndromes. Clindamycin-Benzoyl Peroxide Topical: Uses, Side Effects - WebMD J Infect Dis. and transmitted securely. Serious heart problems could develop later if your infection is not cleared up completely. Hyg. Along with its needed effects, a medicine may cause some unwanted effects. If we combine this information with your protected sharing sensitive information, make sure youre on a federal Bookshelf The patient's symptoms persisted despite tooth extraction and continuance of antibiotic treatment with intravenous, then oral, clindamycin. Clindamycin 1% solution or gel is considered the preferred treatment of the two antibiotics, in part because the risk of bacterial resistance is . Chronic cutaneous lupus in childhood: a report of two cases and review of the literature. Her improvement maintained and her skin clearance was still appreciated at her follow-up visit over 6 months after having initiated the topical clindamycin. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. A 66-year-old woman who took an immunosuppressive agent for a long time was diagnosed with PCP. Pharmacotherapy. Prick and ID test results after 20 min were negative. Description A 64-year-old Caucasian woman was seen in our office for several years for management of her chronic cutaneous lupus erythematosus (CCLE). In this case, the initial -glucan up to 984.6 pg/ml, highly suspected of fungal infection. Older adults may be more sensitive to the effects of this drug, especially diarrhea. Measure the oral liquid correctly using the marked measuring spoon that comes with the package. Br J Dermatol. Cerner Multum, Inc. UK Summary of Product Characteristics. She stopped taking the drug herself because of nausea. An official website of the United States government. Click here for an email preview. Disclaimer. 1998 Aug;39(2 Pt 1):293-5. doi: 10.1016/s0190-9622(98)70096-9. Rarely, may cause severe hypersensitivity reactions and anaphylaxis. clindamycin - Uses, Side Effects, and More - WebMD Br J Dermatol. Do not lie down for at least 10 minutes after taking this medication. the contents by NLM or the National Institutes of Health. Clindamycin. Lobo M.L., Esteves F., de Sousa B. government site. Do not store in the bathroom. Report any instances of severe or persistent diarrhea, occurring either during clindamycin administration or within a few months following discontinuation to your doctor. Antimicrobial agent-induced diarrhea--a bacterial disease. This is to prevent irritation of the esophagus (tube between the throat and stomach). and transmitted securely. Experiences at a single center and a literature review. the unsubscribe link in the e-mail. For more severe infections, 300 to 450 mg every 6 hours. They are available in solutions, lotions, gels, and saturated pads. Br J Dermatol. A patient with chronic cutaneous lupus Clindamycin is an antibiotic that is usually reserved for treating anaerobic infections or other serious infections caused by gram-positive bacteria in penicillin-allergic people. Clindamycin is used to treat certain types of bacterial infections, including infections of the lungs, skin, blood, female reproductive organs, and internal organs. Also, talk to your doctor if you intend to breastfeed while taking clindamycin. If you notice other effects not listed above, contact your doctor or pharmacist. Symptoms of drug-induced lupus tend to occur after taking the drug for at least 3 to 6 months. Before Unable to load your collection due to an error, Unable to load your delegates due to an error. Call your doctor for medical advice about side effects. Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. Tell your health care professional that you are using clindamycin before having any immunizations/vaccinations. Animal studies do not reveal any evidence of teratogenicity and there is not enough data in humans to make a recommendation. Before HHS Vulnerability Disclosure, Help 1981;3:115-20. Tian D, Mohan RJ, Stallings G. Drug rash with eosinophilia and systemic symptoms syndrome associated with clindamycin. The steady-state peak concentrations of SMZ and TMP were monitored on the 4th day after administration, with a SMZ of 43.1 g/ml and a TMP of 8.1 g/ml. Diagnosis: Early considerations related the described dermatologic findings to the dermatologic manifestations of SLE, however findings from lesion biopsy were suggestive of HS. Prednisone and antibiotic therapy with clindamycin were started. health information, we will treat all of that information as protected health [Ref], Common (1% to 10%): Liver function test abnormalities, Frequency not reported: Injection site irritation, pain, abscess formation[Ref], Pain, induration, and sterile abscess have been reported after intramuscular administration. Papakonstantinou E, Mller S, Rhrbein JH, Wieczorek D, Kapp A, Jakob T, Wedi B. You may report them to the FDA. WebMD does not provide medical advice, diagnosis or treatment. Before and transmitted securely. Side effects Warnings Drug interactions Alternatives Summary Clindamycin is an antibiotic. Clindamycin systemic 300 mg (RX693 RX693). Advertising revenue supports our not-for-profit mission. official website and that any information you provide is encrypted To help you remember, take this medication at the same time(s) every day. Abdominal or stomach cramps, pain, or tenderness, blistering, peeling, or loosening of the skin, diarrhea, watery and severe, which may also be bloody, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, rash with flat lesions or small raised lesions on the skin, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips, thick, white vaginal discharge with no odor or with a mild odor. Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Kawachi Y, Taguchi S, Fujisawa Y, Furuta J, Nakamura Y, Ishii Y, Otsuka F. Pediatr Dermatol. Cutaneous adverse reactions to antibiotics | DermNet Li H., Huang H., He H. Successful treatment of severe Pneumocystis pneumonia in an immunosuppressed patient using caspofungin combined with clindamycin: a case report and literature review. PMC A follow-up chest CT scan showed a remarkable improvement after 22 days of the combined therapy (Fig. Chronic cutaneous lupus erythematosus of, Chronic cutaneous lupus erythematosus of the face prior to treatment of topical clindamycin, Chronic cutaneous lupus erythematosus of the face after 3 months of topical clindamycin, MeSH Antiphospholipid syndrome is an autoimmune, acquired thrombophilia diagnosed when vascular thrombosis or pregnancy morbidity are accompanied by persistent antiphospholipid antibodies. Learning points Clindamycin has been demonstrated to have anti-inflammatory properties and utility in the treatment of non-infectious skin conditions. 24. Data sources include IBM Watson Micromedex (updated 3 July 2023), Cerner Multum (updated 10 July 2023), ASHP (updated 10 July 2023) and others. Kapoor R, Flynn C, Heald PW, Kapoor JR. Two days later, the rash improved considerably. 2011 Jul-Aug;86(4 Suppl 1):S89-91. [Ref], Frequency not reported: Polyarthritis[Ref], Frequency not reported: Renal dysfunction, as shown by azotemia, oliguria, and/or proteinuria[Ref], Cleocin, Cleocin Pediatric, Cleocin Phosphate, Cleocin HCl. Thus we cannot ignore the possibility of TMP/SMZ resistance despite the lack of reports on the mutation rates in China. [Ref], Frequency not reported: Anaphylactoid reactions, drug reaction with eosinophilia and systemic systems (DRESS)[Ref], Common (1% to 10%): Thrombophlebitis (after IV infusion), Uncommon (0.1% to 1%): Cardiorespiratory arrest, hypotension[Ref], Cardiorespiratory arrest and hypotension have been reported after too rapid IV administration. 1). -glucan levels can be used to support presumptive diagnosis of PCP, it is also a predictor of therapeutic efficacy in patients with PCP. Biosci Rep. 2019 Dec 20;39(12):BSR20193266. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. As for TMP, individual differences could not be excluded. Patch tests were removed after the 2nd day, and late reactions were evaluated on day 2 and day 4. The site is secure. An official website of the United States government. As a library, NLM provides access to scientific literature. Edman J.C., Kovacs J.A., Masur H., Santi D.V., Elwood H.J., Sogin M.L. This content does not have an English version. Narrative review: the new epidemic of Clostridium difficile-associated enteric disease. Data sources include IBM Watson Micromedex (updated 3 July 2023), Cerner Multum (updated 10 July 2023), ASHP (updated 10 July 2023) and others. 321 Zhongshan Road, Nanjing, 210008, China, bSchool of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, No. However, with the progress of molecular biology techniques, the nucleotide sequence of Pneumocystis jirovecii was found to be more closely related to fungi [6,7], and the similarity was 60%, compared with only 20% of protozoa [8]. 1. Prick and ID tests were assessed after 20 min and 24 hours, respectively. This medicine works best when there is a constant amount in the blood. Eight weeks after clearance of the skin rash, informed consent was obtained in order to perform an allergological evaluation of clindamycin, including prick and intradermal (ID) tests on the forearm and patch tests on the upper back (2). To provide you with the most relevant and helpful information, and understand which Clostridium difficile associated diarrhea (CDAD) has been reported with nearly all antibacterial agents, including clindamycin, and may range in severity from mild diarrhea to life-threatening colitis and has been observed to begin over 2 months after the administration of antibacterial agents. All antibiotics carry a risk of severe diarrhea caused by an overgrowth of. The patient's symptoms developed 2 days after initiating oral clindamycin therapy for a tooth infection. The Koebner isomorphic phenomenon has been described in cutaneous reactions induced by drugs, such as antibiotics and chemotherapy. Available for Android and iOS devices. Miller Quidley A, Bookstaver PB, Gainey AB, Gainey MD. Yao Z., Hua Z., Jun X., Chan W., Xiao-jun M. Lack of response in severe pneumocystis pneumonia to combined caspofungin and clindamycin treatment: a case report. Tell your doctor right away if you develop diarrhea that doesn't stop, abdominal or stomach pain/cramping, or blood/mucus in your stool. If you miss a dose of this medicine, take it as soon as possible. Dis Colon Rectum. Provenance and peer review: Not commissioned; externally peer reviewed. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, stomach/intestinal diseases (such as colitis, C. difficile-associated diarrhea), allergic conditions (such as asthma, hay fever, eczema). Clindamycin is a lincosamide antibiotic that has been approved by the US Food and Drug Administration for the treatment of anaerobic, streptococcal, and staphylococcal infections. 639 Longmian Avenue, Jiangning District, Nanjing, 211198, China, cDepartment of Pharmacy, Zhejiang Hospital, No. The upper back, chest, shoulders and extensor arms are frequent sites. Please enable it to take advantage of the complete set of features! information highlighted below and resubmit the form. To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). Federal government websites often end in .gov or .mil. You should refer to the prescribing information for clindamycin for a complete list of interactions. Before taking clindamycin, tell your doctor or pharmacist if you are allergic to it; or to lincomycin; or if you have any other allergies. 21. This document does not contain all possible drug interactions. other information we have about you. Chronic cutaneous lupus erythematosus and topical clindamycin HHS Vulnerability Disclosure, Help If CDAD is confirmed or suspected, antibiotic therapy not directed against Clostridium difficile may need to be discontinued. As a library, NLM provides access to scientific literature. 12 Lingyin Road, Hangzhou, 310007, China. Efficacy of caspofungin combined with clindamycin for Pneumocystis jirovecii pneumonia in a systemic lupus erythematosus patient: A case report and literature review. Major Pharmaceuticals. It is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents. Drug-induced Sweet's syndrome was determined based on the temporal relationship of the patient's symptoms, the beginning and end of clindamycin therapy, and the exclusion of other etiologies. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Kim T., Hong H.L., Lee Y.M. Would you like email updates of new search results? Clindamycin (Oral Route) Proper Use - Mayo Clinic Capoten Chlorpromazine Methyldopa Sulfasalazine Levamisole, typically as a contaminant of cocaine Cancer immunotherapy drugs such as pembrolizumab can also cause a variety of autoimmune reactions including drug-induced lupus. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Authors Andrew J Newman 1 , Andrea Schneider 2 , Brooke Blumetti 1 , Jason Barr 1 Affiliations 1 Dermatology Residency . Jiang X.Q., Fang L., Mei X.D., Wang X.J., Bao M.H. Common (1% to 10%): Pseudomembranous colitis, diarrhea, abdominal pain, Uncommon (0.1% to 1%): Dysgeusia, nausea, vomiting, Frequency not reported: Esophageal ulcers, esophagitis (oral preparations)[Ref]. Otherwise, call a poison control center right away. Unfortunately, these results are not credible because we found out that she had stopped taking TMP/SMZ by herself for 2 days. Intradermal and patch tests were found to be useful in order to confirm the diagnosis (4,5). Clindamycin is a lincosamide antibiotic. Chronic cutaneous lupus erythematosus of the face after 3 months of topical clindamycin 1%. Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Copyright 1996-2023 Drugs.com. Advertising revenue supports our not-for-profit mission. There is a problem with Careers. Common medications that may interact with clindamycin include: Clindamycin is a substrate of CYP3A4 and to a lesser extent, CYP3A5. The https:// ensures that you are connecting to the This medicine is a turquoise blue, oblong, capsule imprinted with "RX693" and "RX693". Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms. Tell your doctor if you are pregnant before using this medication. Van Ness MM, Cattau EL Jr. Fulminant colitis complicating antibiotic-associated pseudomembranous colitis: case report and review of the clinical manifestations and treatment. Portions of this document last updated: June 01, 2023. Available as an oral capsule, oral solution, and parenterally (may be administered IM or by intermittent or continuous infusion). include protected health information. It is recommended that the more satisfactory therapeutic effects and lower incidence of adverse events can be achieved within a target steady peak concentration of 58 ng/ml for TMP, 100-200 g/ml for SMZ [1].
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